Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.

ABSTRACT: Context:Overt thyroid disease in pregnancy is a known risk factor for abnormal fetal growth and development. Data on the effects of milder forms of variation in maternal thyroid function on intrauterine growth are less well examined. Objective:We explored these associations using repeated thyroid hormone and ultrasound measurements. Design, Setting, and Participants:Data were obtained from 439 pregnant women without diagnosed thyroid disease who were participants in a case-control study of preterm birth nested within an ongoing prospective birth cohort in Boston, Massachusetts. Main Outcome Measures:Ultrasound and delivery indices of fetal growth were standardized to those measured in a larger population. Results:At median 10, 18, and 26 weeks of gestation, we observed significant inverse

SUBMITTER: Johns LE 

PROVIDER: S-EPMC6018657 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature