Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.

ABSTRACT: Inflammation plays an important role in the development of atherosclerosis and its complications. Because the folate receptor β (FR-β) is selectively expressed on macrophages, an FR targeted imaging agent could be useful for assessment of atherosclerotic inflammation. We investigated aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid conjugated folate (¹⁸F-FOL) for the detection of atherosclerotic plaque inflammation. We studied atherosclerotic plaques in mice, rabbits, and human tissue samples using ¹⁸F-FOL positron emission tomography/computed tomography (PET/CT). Compound 2-deoxy-2-[¹⁸F]fluoro-D-glucose (¹⁸F-FDG) was used as a comparison. Firstly, we found that the in vitro binding of ¹⁸F-FOL co-localized with

SUBMITTER: Silvola JMU 

PROVIDER: S-EPMC6018703 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature