Re-assessment of multiple testing strategies for more efficient genome-wide association studies.

ABSTRACT: Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome-wide association studies (GWASs), only a small fraction of estimated heritability can be explained by these results. This is the so-called missing heritability problem. The conventional use of overly conservative multiple testing strategies based on controlling the familywise error rate (FWER), in particular with a genome-wide significance threshold of P <5 × 10-8, is one of the most important issues from a statistical perspective. To help resolve this problem, we performed comprehensive re-assessments of currently available strategies using recently published, extremely large-scale GWAS data sets of rheumatoid arthritis and schizophrenia (>50,000 subjects). The estima

SUBMITTER: Otani T 

PROVIDER: S-EPMC6018732 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature