Role of copy number variants in sudden cardiac death and related diseases: genetic analysis and translation into clinical practice.

ABSTRACT: Several studies have identified copy number variants (CNVs) as responsible for cardiac diseases associated with sudden cardiac death (SCD), but very few exhaustive analyses in large cohorts of patients have been performed, and they have been generally focused on a specific SCD-related disease. The aim of the present study was to screen for CNVs the most prevalent genes associated with SCD in a large cohort of patients who suffered sudden unexplained death or had an inherited cardiac disease (cardiomyopathy or channelopathy). A total of 1765 European patients were analyzed with a homemade algorithm for the assessment of CNVs using high-throughput sequencing data. Thirty-six CNVs were identified (2%), and most of them appeared to have a pathogenic role. The frequency of CNVs among cases of s

SUBMITTER: Mates J 

PROVIDER: S-EPMC6018743 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature