Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories.

ABSTRACT: Cognitive and brain development are determined by dynamic interactions between genes and environment across the lifespan. Aside from marker-by-marker analyses of polymorphisms, biologically meaningful features of the whole genome (derived from the combined effect of individual markers) have been postulated to inform on human phenotypes including cognitive traits and their underlying biological substrate. Here, estimates of inbreeding and genetic susceptibility for schizophrenia calculated from genome-wide data-runs of homozygosity (ROH) and schizophrenia polygenic risk score (PGRS)-are analyzed in relation to cognitive abilities (n = 4183) and brain structure (n = 516) in a general-population sample of European-ancestry participants aged 8-22, from the Philadelphia Neurodevelopmental Cohor

SUBMITTER: Cordova-Palomera A 

PROVIDER: S-EPMC6018758 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature