Genotype Influences Day-to-Day Variability in Sleep in Drosophila melanogaster.

ABSTRACT: Patterns of sleep often vary among individuals. But sleep and activity may also vary within an individual, fluctuating in pattern across time. One possibility is that these daily fluctuations in sleep are caused by the underlying genotype of the individual. However, differences attributable to genetic causes are difficult to distinguish from environmental factors in outbred populations such as humans. We therefore employed Drosophila as a model of intra-individual variability in sleep using previously collected sleep and activity data from the Drosophila Genetic Reference Panel, a collection of wild-derived inbred lines. Individual flies had significant daily fluctuations in their sleep patterns, and these fluctuations were heritable. Using the standard deviation of sleep parameters as a m

SUBMITTER: Wu KJ 

PROVIDER: S-EPMC6018780 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature