COMT Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia.

ABSTRACT:

Introduction

The COMT Val 108/158 Met polymorphism (rs4680) may affect treatment response to antipsychotics, as well as metabolism and dynamics of neurotransmitters during the treatment of schizophrenia. We investigated the effects of the COMT Val 108/158 Met polymorphism on treatment response to aripiprazole and plasma monoamine metabolite levels in patients with acute schizophrenia.

Materials and methods

Forty patients with schizophrenia were treated with aripiprazole for 6 weeks. We measured Positive and Negative Syndrome Scale (PANSS) and plasma levels of homovanillic acid (HVA) and plasma MHPG (3-methoxy-4-hydroxyphenethyleneglycol) at baseline and endpoint. The COMT Val 108/158 Met polymorphism was genotyped with the polymerase chain reaction and r

SUBMITTER: Kaneko H 

PROVIDER: S-EPMC6018926 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature