Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size.

ABSTRACT: Estimating the size of the viral reservoir is critical for HIV cure strategies. Biomarkers in peripheral circulation may give insights into the establishment of the viral reservoir in compartments not easily accessible. We therefore measured systemic levels of 84 soluble biomarkers belonging to a broad array of immune pathways in acute HIV infection in both antiretroviral therapy-naive (ART-naive) individuals as well as individuals who began ART upon early detection of HIV infection. These biomarkers were measured longitudinally during acute and chronic infection and their relationship to viral reservoir establishment and persistence was assessed. We observed several distinct biomarker pathways induced following HIV infection such as IFN-γ-signaled chemokines, proinflammatory markers, and

SUBMITTER: Teigler JE 

PROVIDER: S-EPMC6018979 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature