Predictive approaches for drug combination discovery in cancer.

ABSTRACT: Drug combinations have been proposed as a promising therapeutic strategy to overcome drug resistance and improve efficacy of monotherapy regimens in cancer. This strategy aims at targeting multiple components of this complex disease. Despite the increasing number of drug combinations in use, many of them were empirically found in the clinic, and the molecular mechanisms underlying these drug combinations are often unclear. These challenges call for rational, systematic approaches for drug combination discovery. Although high-throughput screening of single-agent therapeutics has been successfully implemented, it is not feasible to test all possible drug combinations, even for a reduced subset of anticancer drugs. Hence, in vitro and in vivo screening of a large number of drug combinations a

SUBMITTER: Madani Tonekaboni SA 

PROVIDER: S-EPMC6018991 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature