Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy.

ABSTRACT:

Aims

To determine whether fibrin clot properties are associated with clinical outcomes following acute coronary syndrome (ACS).

Methods and results

Plasma samples were collected at hospital discharge from 4354 ACS patients randomized to clopidogrel or ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. A validated turbidimetric assay was employed to study plasma clot lysis time and maximum turbidity (a measure of clot density). One-year rates of cardiovascular (CV) death, spontaneous myocardial infarction (MI) and PLATO-defined major bleeding events were assessed after sample collection. Hazard ratios (HRs) were estimated using Cox proportional hazards models. After adjusting for CV risk factors, each 50% increase in lysis time was associated with CV de

SUBMITTER: Sumaya W 

PROVIDER: S-EPMC6019045 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature