Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.

ABSTRACT: Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Ex

SUBMITTER: Kaucka M 

PROVIDER: S-EPMC6019068 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature