Implantation Depth and Rotational Orientation Effect on Valve-in-Valve Hemodynamics and Sinus Flow.

ABSTRACT:

Background

This study evaluated the effect of transcatheter aortic valve implantation depth and rotation on pressure gradient (PG), leakage fractions (LF), leaflet shear stress, and sinus washout in an effort to understand factors that may dictate optimal positioning for valve-in-valve (ViV) procedures. Sinus flow stasis is often associated with prosthetic leaflet thrombosis. Although recent ViV in vitro studies highlighted potential benefits of transcatheter aortic valve supraannular implantation to minimize PGs, the relationship between transcatheter aortic valve depth and other determinates of valve function remains unknown. Among these, LFs, shear stress, and poor sinus washout have been associated with poorer valve outcomes.

Methods

ViV hemodynamic performance was evalu

SUBMITTER: Hatoum H 

PROVIDER: S-EPMC6019140 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature