A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT).

ABSTRACT:

Background

Poor adherence to immunosuppressive medications is a major cause of premature graft loss among children and young adults. Multicomponent interventions have shown promise but have not been fully evaluated.

Study design

Unblinded parallel-arm randomized trial to assess the efficacy of a clinic-based adherence-promoting intervention.

Setting & participants

Prevalent kidney transplant recipients 11 to 24 years of age and 3 or more months posttransplantation at 8 kidney transplantation centers in Canada and the United States (February 2012 to May 2016) were included.

Intervention

Adherence was electronically monitored in all participants during a 3-month run-in, followed by a 12-month intervention. Participants assigned to the TAKE-IT intervention could c

SUBMITTER: Foster BJ 

PROVIDER: S-EPMC6019162 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature