Diastolic dysfunction is associated with exercise impairment in patients with sickle cell anemia.

ABSTRACT:

Background

Left ventricular diastolic dysfunction (DD) is an independent risk factor for mortality in sickle cell anemia (SCA) and is associated with increased extracellular volume (ECV) on cardiac MRI (CMR). Exercise impairment is common in SCA, but its causes and prognostic value are not well understood.

Objective

To study the effects of DD and ECV on cardiopulmonary exercise test (CPET) in patients with SCA.

Methods and results

As part of a prospective study to characterize the cardiomyopathy of SCA (NCT02410811), 20 children and adults with SCA underwent CMR, echocardiography, and cycle ergometer CPET (age range 8-43 years). Maximum exercise was reached in 18 patients and 17 (94%) had reduced exercise capacity (%predicted VO₂ less than 80%). Six patient

SUBMITTER: Alsaied T 

PROVIDER: S-EPMC6019177 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature