Systematic review with meta-analysis: recurrence of hepatocellular carcinoma following direct-acting antiviral therapy.

ABSTRACT:

Background

Although studies suggest decreased incident hepatocellular carcinoma (HCC) after direct-acting antivirals (DAA), data are conflicting regarding HCC recurrence and aggressiveness in patients who have a history of HCC with complete response.

Aim

Characterize HCC recurrence patterns after DAA therapy.

Methods

Two reviewers searched MEDLINE and SCOPUS from January 2015 to December 2017 and identified studies evaluating HCC recurrence patterns following DAA therapy. A pooled estimate was calculated using the DerSimonian and Laird method for a random effects model. The study was conducted in accordance with PRISMA guidelines.

Results

Among 24 studies (n = 1820 patients), the proportion of patients with HCC recurrence following DAA therapy ranged from 0% to

SUBMITTER: Saraiya N 

PROVIDER: S-EPMC6019180 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature