Peptide coatings enhance keratinocyte attachment towards improving the peri-implant mucosal seal.

ABSTRACT: There is a critical need for preventing peri-implantitis as its prevalence has increased and dental implants lack features to prevent it. Research strategies to prevent peri-implantitis have focused on modifying dental implants to incorporate different antimicrobial agents. An alternative strategy consists of barring the expansion of the biofilm subgingivally by forming a long-lasting permucosal seal between the soft tissue and the implant surface. Here, we innovatively biofunctionalized titanium with bioinspired peptide coatings to strengthen biological interactions between epithelial cells and the titanium surface. We selected laminin 332- and ameloblastin-derived peptides (Lam, Ambn). Laminin 332 participates in the formation of hemidesmosomes by keratinocytes and promotes epithelial at

SUBMITTER: Koidou VP 

PROVIDER: S-EPMC6019193 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature