Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice.

ABSTRACT:

Background

Cardiovascular disease is the leading cause of mortality in the advanced world, and age is an important determinant of cardiac function. The purpose of the study is to determine whether the PM_2.5-induced cardiac dysfunction is age-dependent and whether the adverse effects can be restored after PM_2.5 exposure withdrawal.

Methods

Female C57BL/6 mice at different ages (4-week-old, 4-month-old, and 10-month-old) received oropharyngeal aspiration of 3 mg/kg b.w. PM_2.5 every other day for 4 weeks. Then, 10-month-old and 4-week-old mice were exposed to PM_2.5 for 4 weeks and withdrawal PM_2.5 1 or 2 weeks. Heart rate and systolic blood pressure were measured using a tail-cuff system. Cardiac function was assessed by ec

SUBMITTER: Qin G 

PROVIDER: S-EPMC6019275 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature