Ciliated conical epithelial cell protrusions point towards a diagnosis of primary ciliary dyskinesia.

ABSTRACT:

Background

Primary ciliary dyskinesia can result from a number of different ciliary defects that adversely affect ciliary function resulting markedly reduced or absent mucociliary clearance. Improvement in diagnostic testing is an area of current research. During diagnostic evaluation of PCD we observed ciliated conical protrusions from part of the apical surface of ciliated cells in those diagnosed with PCD. The aim of this study was to investigate if this abnormality was specific to PCD.

Methods

Epithelial edges from 67 consecutively diagnosed PCD patients, 67 patients consecutively referred for PCD diagnostic testing in whom PCD was excluded, 22 with asthma and 18 with Cystic Fibrosis (CF) were studied retrospectively in a blinded manner using light microscopy.

Results

SUBMITTER: O'Callaghan C 

PROVIDER: S-EPMC6019300 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature