Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.

ABSTRACT: Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, injury to individual tissues is followed by local and systemic compensatory mechanisms that allow the damaged tissue to regain normal proportions with other tissues. In vertebrates, local catch-up growth has been described after transient reduction of bone growth, but the underlying cellular responses are controversial. We developed an approach to study catch-up growth in foetal mice in which mosaic expression of the cell cycle suppressor p21 is induced in the cartilage cells (chondrocytes) that drive long-bone elongation. By specifically targeting p21 expression to left hindlimb chondrocytes, the right limb serves as an internal control. Unexpectedly, left-right limb symmetry

SUBMITTER: Rosello-Diez A 

PROVIDER: S-EPMC6019387 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature