Proteome-wide analysis of human motif-domain interactions mapped on influenza a virus.

ABSTRACT:

Background

The influenza A virus (IAV) is a constant threat for humans worldwide. The understanding of motif-domain protein participation is essential to combat the pathogen.

Results

In this study, a data mining approach was employed to extract influenza-human Protein-Protein interactions (PPI) from VirusMentha,Virus MINT, IntAct, and Pfam databases, to mine motif-domain interactions (MDIs) stored as Regular Expressions (RegExp) in 3DID database. A total of 107 RegExp related to human MDIs were searched on 51,242 protein fragments from H1N1, H1N2, H2N2, H3N2 and H5N1 strains obtained from Virus Variation database. A total 46 MDIs were frequently mapped on the IAV proteins and shared between the different strains. IAV kept host-like MDIs that were associated with the virus su

SUBMITTER: Garcia-Perez CA 

PROVIDER: S-EPMC6019528 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature