Closed-loop intracranial stimulation alters movement timing in humans.

ABSTRACT:

Background

A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just prior to voluntary movement.

Objective

Here, we tested a method that detected activity in the human SMA related to impending movement and then delivered cortical stimulation with intracranial electrodes to influence the timing of movement.

Methods

We conducted experiments in nine patients with electrodes implanted for epilepsy localization: five patients with SMA electrodes and four control patients with electrodes outside the SMA. In the first experiment

SUBMITTER: Moore BD 

PROVIDER: S-EPMC6019631 | biostudies-literature | 2018 Jul - Aug

REPOSITORIES: biostudies-literature