Dysbiotic Subgingival Microbial Communities in Periodontally Healthy Patients With Rheumatoid Arthritis.

ABSTRACT:

Objective

Studies that demonstrate an association between rheumatoid arthritis (RA) and dysbiotic oral microbiomes are often confounded by the presence of extensive periodontitis in these individuals. This study was undertaken to investigate the role of RA in modulating the periodontal microbiome by comparing periodontally healthy individuals with RA to those without RA.

Methods

Subgingival plaque was collected from periodontally healthy individuals (22 with RA and 19 without RA), and the 16S gene was sequenced on an Illumina MiSeq platform. Bacterial biodiversity and co-occurrence patterns were examined using the QIIME and PhyloToAST pipelines.

Results

The subgingival microbiomes differed significantly between patients with RA and controls based on both community mem

SUBMITTER: Lopez-Oliva I 

PROVIDER: S-EPMC6019644 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature