A CD8α- Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment.

ABSTRACT:

Objective

An unconventional population of CD4+ signaling lymphocytic activation molecule family member 7-positive (SLAMF7+) cytotoxic effector memory T (T_EM ) cells (CD4+ cytotoxic T lymphocytes [CTLs]) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first-line therapeutic approach in patients with IgG4-RD, but their mechanism of action in this specific condition remains unknown. We undertook this study to determine the impact of glucocorticoids on CD4+ CTLs in IgG4-RD.

Methods

Expression of CD8α, granzyme A, perforin, and SLAMF7 within the effector memory compartment of CD45RO+ (T_EM ) and CD45RA+ effector memory T (T_EMRA ) CD4+ cells was quantified by flow cytometry in 18 patients with active IgG4-RD

SUBMITTER: Della-Torre E 

PROVIDER: S-EPMC6019645 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature