The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells.

ABSTRACT:

Background

Arrhythmogenic cardiomyopathy (ACM) is a genetic autosomal disease characterized by abnormal cell-cell adhesion, cardiomyocyte death, progressive fibro-adipose replacement of the myocardium, arrhythmias and sudden death. Several different cell types contribute to the pathogenesis of ACM, including, as recently described, cardiac stromal cells (CStCs). In the present study, we aim to identify ACM-specific expression profiles of human CStCs derived from endomyocardial biopsies of ACM patients and healthy individuals employing TaqMan Low Density Arrays for miRNA expression profiling, and high throughput sequencing for gene expression quantification.

Results

We identified 3 miRNAs and 272 genes as significantly differentially expressed at a 5% false discovery rate. Bo

SUBMITTER: Rainer J 

PROVIDER: S-EPMC6019788 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature