Association of NOS1 gene polymorphisms with cerebral palsy in a Han Chinese population: a case-control study.

ABSTRACT:

Background

Cerebral palsy (CP) is the leading cause of motor disability in children; however, its pathogenesis is unknown in most cases. Growing evidence suggests that Nitric oxide synthase 1 (NOS1) is involved in neural development and neurologic diseases. The purpose of this study was to determine whether genetic variants of NOS1 contribute to CP susceptibility in a Han Chinese population.

Methods

A case-control study involving 652 CP patients and 636 healthy controls was conducted. Six SNPs in the NOS1 gene (rs3782219, rs6490121, rs2293054, rs10774909, rs3741475, and rs2682826) were selected, and the MassARRAY typing technique was applied for genotyping. Data analysis was conducted using SHEsis online software, and multiple test corrections were performed using SNPSpD onl

SUBMITTER: Yu T 

PROVIDER: S-EPMC6019815 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature