Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study.

ABSTRACT:

Objective

To evaluate the relation between penicillin allergy and development of meticillin resistant Staphylococcus aureus (MRSA) and C difficile.

Design

Population based matched cohort study.

Setting

United Kingdom general practice (1995-2015).

Participants

301 399 adults without previous MRSA or C difficile enrolled in the Health Improvement Network database: 64 141 had a penicillin allergy and 237 258 comparators matched on age, sex, and study entry time.

Main outcome measures

The primary outcome was risk of incident MRSA and C difficile. Secondary outcomes were use of β lactam antibiotics and β lactam alternative antibiotics.

Results

Among 64 141 adults with penicillin allergy and 237 258 matched comparators, 1365

SUBMITTER: Blumenthal KG 

PROVIDER: S-EPMC6019853 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature