Recombinant human lactoferrin modulates human PBMC derived macrophage responses to BCG and LPS.

ABSTRACT: Lactoferrin, an iron-binding glycoprotein found in mammalian mucosal secretions and granules of neutrophils, possesses several immune modulatory properties. Published reports indicate that lactoferrin enhances the efficacy of the tuberculosis vaccine, BCG (Bacillus Calmette Guerin), both by increasing macrophage and dendritic cell ability to stimulate receptive T cells and by modulating the inflammatory response. This report is the first to demonstrate the effects of a recombinant human lactoferrin (10 μg/mL) on human PBMC derived CD14⁺ and CD16⁺ macrophages stimulated with a strong (LPS, 10 ng/mL) or weaker (BCG, MOI 1:1) stimulator of inflammation. After 3 days culture, LPS and human lactoferrin treated CD14⁺ cells significantly increased production of IL

SUBMITTER: Hwang SA 

PROVIDER: S-EPMC6020075 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature