Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy.

ABSTRACT:

Background

To compare the abundance of vitreous proteins between the patients with proliferative diabetic retinopathy (PDR) and idiopathic macular hole (IMH).

Methods

In this study, we performed mass spectrometry-based label-free quantitative proteomics analysis of vitreous samples from type 2 diabetic patients with PDR (n = 9) and IMH subjects (n = 9) and identified the abundance of 610 proteins.

Results

Out of 610 proteins, 64 proteins (Group A) were unique to PDR patients, while 212 proteins (Group B) could be identified in IMH vitreous only. Among the other 334 proteins that could be detected in both PDR and IMH eyes, 62 proteins differed significantly (p < 0.05, fold change > 2), which included 52 proteins (Group C) and 10 proteins (Group D) over- and under-expre

SUBMITTER: Li J 

PROVIDER: S-EPMC6020172 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature