CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness.

ABSTRACT:

Background

Population phenotypic variation can arise from genetic differences between individuals, or from cellular heterogeneity in an isogenic group of cells or organisms. The emergence of gene expression differences between genetically identical cells is referred to as gene expression noise, the sources of which are not well understood.

Results

In this work, by studying gene expression noise between multiple cell lineages and mammalian species, we find consistent evidence of a role for CpG islands as sources of gene expression noise. Variation in noise among CpG island promoters can be partially attributed to differences in island size, in which short islands have noisier gene expression. Building on these findings, we investigate the potential for short CpG islands to ac

SUBMITTER: Morgan MD 

PROVIDER: S-EPMC6020341 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature