Post-translational buffering leads to convergent protein expression levels between primates.

ABSTRACT:

Background

Differences in gene regulation between human and closely related species influence phenotypes that are distinctly human. While gene regulation is a multi-step process, the majority of research concerning divergence in gene regulation among primates has focused on transcription.

Results

To gain a comprehensive view of gene regulation, we surveyed genome-wide ribosome occupancy, which reflects levels of protein translation, in lymphoblastoid cell lines derived from human, chimpanzee, and rhesus macaque. We further integrated messenger RNA and protein level measurements collected from matching cell lines. We find that, in addition to transcriptional regulation, the major factor determining protein level divergence between human and closely related species is post-tra

SUBMITTER: Wang SH 

PROVIDER: S-EPMC6020354 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature