Efficacy of initial haemopurification strategy for acute paraquat poisoning in adults: study protocol for a randomised controlled trial (HeSAPP).

ABSTRACT:

Introduction

Paraquat (PQ) is a widely used herbicide which is inexpensive and easily accessible for people in rural areas. A small amount of PQ ingestion could be lethal, yet currently, the optimal treatment is still controversial. Extracorporeal therapies (ECTR) have been practised in PQ poisoning management, though limited evidence could be obtained to suggest its superiority over conservative therapy. Haemodialysis (HD) and haemoperfusion (HP) are most commonly used, while some institutions also choose HP-HD concurrent therapy. The object of the present trial is to investigate whether haemopurification therapy can reduce mortality compared with conservative therapy.

Methods and analysis

This is a planned single-centre, non-blinded, randomised controlled trial. Acute PQ p

SUBMITTER: Cui JW 

PROVIDER: S-EPMC6020939 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature