Comparative safety of bowel cleansers: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

The US Food and Drug Administration has withdrawn the bowel cleansing kit HalfLytely (PEG 3500) with 10 mg bisacodyl tablets due to an increased risk of ischaemic colitis compared with the same kit with only 5 mg bisacodyl. This is of interest in Canada given that the bowel cleansing kit Bi-Peglyte (PEG 3500) with 15 mg bisacodyl is currently approved for use. The objective is to assess the comparative safety of various bowel cleansers with or without bisacodyl, with a primary interest inpolyethylene glycol (PEG)-based and sodium-picosulfate-based products.

Methods and analysis

Given the existing volume of the literature, the review will be conducted in two stages. Stage 1 will consist of a scoping exercise by searching MEDLINE, Embase and the Cochrane Library (

SUBMITTER: Barbeau P 

PROVIDER: S-EPMC6020982 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature