Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway.

ABSTRACT:

Background

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that adversely affect human health. PCBs bio-accumulate in organisms important for human consumption. PCBs accumulation in the body leads to activation of the transcription factor NF-κB, a major driver of inflammation. Despite dietary exposure being one of the main routes of exposure to PCBs, the gut has been widely ignored when studying the effects of PCBs.

Objectives

We investigated the effects of PCB 153 on the intestine and addressed whether PCB 153 affected intestinal permeability or inflammation and the mechanism by which this occurred.

Methods

Mice were orally exposed to PCB 153 and gut permeability was assessed. Intestinal epithelial cells (IECs) were collected and evaluated for evid

SUBMITTER: Phillips MC 

PROVIDER: S-EPMC6021014 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature