New susceptibility loci for cutaneous melanoma risk and progression revealed using a porcine model.

ABSTRACT: Despite major advances, it is estimated that a large part of melanoma predisposing genes remains to be discovered. Animal models of spontaneous diseases are valuable tools and experimental crosses can be used to identify and fine-map new susceptibility loci associated with melanoma. We performed a Genome-Wide Association Study (GWAS) of melanoma occurrence and progression (clinical ulceration and presence of metastasis) in a porcine model of spontaneous melanoma, the MeLiM pig. Five loci on chromosomes 2, 5, 7, 8 and 16 showed genome-wide significant associations (p < 5 × 10^-6) with either one of these phenotypes. Suggestive associations (p < 5 × 10^-5) were also found at 16 additional loci. Moreover, comparison of the porcine results to those reported by

SUBMITTER: Bourneuf E 

PROVIDER: S-EPMC6021234 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature