Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging.

ABSTRACT: Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although prior studies have explored the functional consequences of macrophage aging, less is known about its cellular basis or what defines the transition from physiologic aging to disease. Here, we show that despite their frequent self-renewal, macrophages from old mice exhibited numerous signs of aging, such as impaired oxidative respiration. Transcriptomic profiling of aged murine macrophages revealed dysregulation of diverse cellular pathways, especially in cholesterol homeostasis, that manifested in altered oxysterol signatures. Although the levels of numerous oxysterols in human peripheral blood mononuclear cells and plasma exhibited ag

SUBMITTER: Lin JB 

PROVIDER: S-EPMC6021272 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature