Probiotic DSF counteracts chemotherapy induced neuropathic pain.

ABSTRACT:

Problem statement

Chemotherapy-induced peripheral neuropathy (CIPN) is a widespread and potentially disabling side effect of various anticancer drugs. In spite of the intensive research focused on obtaining therapies capable to treat or prevent CIPN, the medical demand remains very high. Microtubule-stabilizing agents, among which taxanes, are effective chemotherapeutic agents for the therapy of several oncologic diseases. The inflammatory process activated by chemotherapeutic agents has been interpreted as a potential trigger of the nociceptive process in CIPN. The chemotherapy-driven release of proinflammatory and chemokines has been recognized as one of the principal mechanisms controlling the establishment of CIPN. Several reports have indicated that probiotics are capable to r

SUBMITTER: Castelli V 

PROVIDER: S-EPMC6021327 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature