Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles.

ABSTRACT: Several classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially improve the patients management. Gene amplification profiles were prospectively evaluated in 80 primary glioblastoma multiforme tumors using single-nucleotide polymorphism arrays and the results obtained validated in publicly available data from 267/347 cases. Gene amplification was detected in 45% of patients, and chromosome 7p11.2 including the EGFR gene, was the most frequently

SUBMITTER: Gonzalez-Tablas M 

PROVIDER: S-EPMC6021328 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature