HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

ABSTRACT: Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials. Its failure provokes genetically unstable states, such as tetraploidization and polyploidization, which can contribute to tumorigenesis. Aurora-B kinase controls multiple cytokinetic events, from chromosome condensation to abscission when the midbody is severed. We have previously shown that HIPK2, a kinase involved in DNA damage response and development, localizes at the midbody and contributes to abscission by phosphorylating extrachromosomal histone H2B at Ser14. Of relevance, HIPK2-defective cells do not phosphorylate H2B and do not successfully complete cytokinesis leading to accumulation of binucleated cells, chromosomal insta

SUBMITTER: Monteonofrio L 

PROVIDER: S-EPMC6021368 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature