Ontology highlight
ABSTRACT:
SUBMITTER: Jiao J
PROVIDER: S-EPMC6021382 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature communications 20180627 1
To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT3 activity via negatively regulating the Protein Inhibitors of Activated STAT3 (PIAS3). Mechanically, Smad6 interacts directly with PIAS3, and this interaction is mediated through the Mad homology 2 ( ...[more]