Origin and classification of spontaneous discharges in mouse superficial dorsal horn neurons.

ABSTRACT: Superficial laminae of the spinal cord possess a considerable number of neurons with spontaneous activity as reported in vivo and in vitro preparations of several species. Such neurons may play a role in the development of the nociceptive system and/or in the spinal coding of somatosensory signals. We have used electrophysiological techniques in a horizontal spinal cord slice preparation from adult mice to investigate how this activity is generated and what are the main patterns of activity that can be found. The results show the existence of neurons that fire regularly and irregularly. Within each of these main types, it was possible to distinguish patterns of spontaneous activity formed by single action potentials and different types of bursts according to intra-burst firing frequency. A

SUBMITTER: Lucas-Romero J 

PROVIDER: S-EPMC6021406 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature