GABA promotes survival and axonal regeneration in identifiable descending neurons after spinal cord injury in larval lampreys.

ABSTRACT: The poor regenerative capacity of descending neurons is one of the main causes of the lack of recovery after spinal cord injury (SCI). Thus, it is of crucial importance to find ways to promote axonal regeneration. In addition, the prevention of retrograde degeneration leading to the atrophy/death of descending neurons is an obvious prerequisite to activate axonal regeneration. Lampreys show an amazing regenerative capacity after SCI. Recent histological work in lampreys suggested that GABA, which is massively released after a SCI, could promote the survival of descending neurons. Here, we aimed to study if GABA, acting through GABAB receptors, promotes the survival and axonal regeneration of descending neurons of larval sea lampreys after a complete SCI. First, we used in situ hybridizatio

SUBMITTER: Romaus-Sanjurjo D 

PROVIDER: S-EPMC6021415 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature