A cylindrical assembly model and dynamics of the Ebola virus VP40 structural matrix.

ABSTRACT: The Ebola filovirus causes severe hemorrhagic fever with a high fatality rate in humans. The primary structural matrix protein VP40 displays transformer-protein characteristics and exists in different conformational and oligomeric states. VP40 plays crucial roles in viral assembly and budding at the plasma membrane of the infected cells and is capable of forming virus-like particles without the need for other Ebola proteins. However, no experimental three-dimensional structure for any filovirus VP40 cylindrical assembly matrix is currently available. Here, we use a protein-protein docking approach to develop cylindrical assembly models for an Ebola virion and also for a smaller structural matrix that does not contain genetic material. These models match well with the 2D averages of cryo-el

SUBMITTER: Pavadai E 

PROVIDER: S-EPMC6021417 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature