Virtual reality-based cognitive-motor training for middle-aged adults at high Alzheimer's disease risk: A randomized controlled trial.

ABSTRACT:

Introduction

Ubiquity of Alzheimer's disease (AD) coupled with relatively ineffectual pharmacologic treatments has spurred interest in nonpharmacologic lifestyle interventions for prevention or risk reduction. However, evidence of neuroplasticity notwithstanding, there are few scientifically rigorous, ecologically relevant brain training studies focused on building cognitive reserve in middle age to protect against cognitive decline. This pilot study will examine the ability of virtual reality (VR) cognitive training to improve cognition and cerebral blood flow (CBF) in middle-aged individuals at high AD risk due to parental history.

Methods

The design is an assessor-blind, parallel group, randomized controlled trial of VR cognitive-motor training in middle-aged adults with

SUBMITTER: Doniger GM 

PROVIDER: S-EPMC6021455 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature