Conductivity Rise During Irreversible Electroporation: True Permeabilization or Heat?

ABSTRACT:

Purpose

Irreversible electroporation (IRE) induces apoptosis with high-voltage electric pulses. Although the working mechanism is non-thermal, development of secondary Joule heating occurs. This study investigated whether the observed conductivity rise during IRE is caused by increased cellular permeabilization or heat development.

Methods

IRE was performed in a gelatin tissue phantom, in potato tubers, and in 30 patients with unresectable colorectal liver metastases (CRLM). Continuous versus sequential pulsing protocols (10-90 vs. 10-30-30-30) were assessed. Temperature was measured using fiber-optic probes. After temperature had returned to baseline, 100 additional pulses were delivered. The primary technique efficacy of the treated CRLM was compared to the periprocedural

SUBMITTER: Ruarus AH 

PROVIDER: S-EPMC6021471 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature