Donepezil may reduce the risk of comorbidities in patients with Alzheimer's disease: A large-scale matched case-control analysis in Japan.

ABSTRACT:

Introduction

Few studies have focused on the association between donepezil and physical comorbid conditions in Alzheimer's disease patients.

Methods

We investigated the association between donepezil prescription and the occurrences of comorbidities in Alzheimer's disease patients, by using an electronic medical records database which contains case-based information on approximately three million patients from more than 60 hospitals across Japan.

Results

Nine thousand seven hundred forty-nine patients had at least one diagnosis of Alzheimer's disease between 2001 and 2015. To test the robustness of the results, we used a risk set sampling method, and the matched cohorts based on age, sex, comorbidity level, and duration of illness consisted of 1406 cases and an equal n

SUBMITTER: Kobayashi H 

PROVIDER: S-EPMC6021551 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature