Association of Genetic Polymorphisms with Atopic Dermatitis, Clinical Severity and Total IgE: A Replication and Extended Study.

ABSTRACT:

Purpose

Atopic dermatitis (AD) is a common and chronic inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide. Although previous reports including genome-wide association study (GWAS) approaches have identified several risk factors that appear to be associated with AD development, replication studies are lacking. In our current study, we replicated the associations between candidate susceptibility loci and AD.

Methods

A total of 885 Korean subjects (425 AD patients and 460 unaffected controls) were genotyped for 17 single nucleotide polymorphisms (SNPs) from previous GWASs and meta-analyses of AD and from immune-related genes.

Results

Several SNPs showed significant associations with AD in the case-control analysis (minimum P=0.005 at rs1

SUBMITTER: Kim JH 

PROVIDER: S-EPMC6021591 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature