A Population Pharmacokinetic Model for a Solid Oral Tablet Formulation of Posaconazole.

ABSTRACT: A delayed-release solid tablet formulation that releases posaconazole in the small intestine was developed to maximize systemic absorption. This study aimed to characterize the pharmacokinetics of the posaconazole solid tablet formulation in adult subjects and to investigate the potential impact of demographic and clinical factors on posaconazole exposure through a population pharmacokinetic approach. Nonlinear mixed-effects modeling was performed using data from several studies conducted in healthy volunteers and patients. The influence of demographic and clinical factors on pharmacokinetic parameters was evaluated using a stepwise forward inclusion/backward exclusion procedure. The final pharmacokinetic model was used to simulate posaconazole exposure in patients at high risk for invasiv

SUBMITTER: van Iersel MLPS 

PROVIDER: S-EPMC6021660 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature