Characterizing Blood-Stage Antimalarial Drug MIC Values In Vivo Using Reinfection Patterns.

ABSTRACT: The MIC is an essential quantitative measure of the asexual blood-stage effect of an antimalarial drug. In areas of high malaria transmission, and thus frequent individual infection, patients who are treated with slowly eliminated antimalarials become reinfected as drug concentrations decline. In the frequent relapse forms of Plasmodium vivax and in Plasmodium ovale malaria, recurrent infection occurs from relapses which begin to emerge from the liver approximately 2 weeks after the primary illness. An important determinant of the interval from starting treatment of a symptomatic infection to the patency of these recurrent infections is the in vivo concentration-response relationship and thus the in vivo MIC. Using mechanistic knowledge of parasite asexual replication and the pharmacokinet

SUBMITTER: Watson J 

PROVIDER: S-EPMC6021672 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature