A reactivity-based [¹⁸F]FDG probe for in vivo formaldehyde imaging using positron emission tomography.

ABSTRACT: Formaldehyde (FA) is a reactive carbonyl species (RCS) that plays a broad spectrum of roles in epigenetics, toxicology, and progression of diseases ranging from cancer to diabetes to neurodegeneration, motivating the development of translatable technologies for FA imaging. Here we report formaldehyde-caged-[¹⁸F]fluorodeoxyglucose-1 ([¹⁸F]FAC-FDG-1), an aza-Cope-based reactivity probe for in vivo FA imaging using positron emission tomography (PET). [¹⁸F]FAC-FDG-1 reacts selectively with FA over potentially competing analytes to generate [¹⁸F]FDG, allowing its FA-dependent uptake and retention in cell culture as well as in animal models. The relative uptake of [¹⁸F]FAC-FDG-1 was evaluated using FA-treated PC3 prostate cancer and U

SUBMITTER: Liu W 

PROVIDER: S-EPMC6021783 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature