Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.

ABSTRACT:

Aim

Multiple genetic variants have been associated with variation in tacrolimus (TAC) trough concentrations. Unfortunately, additional studies do not confirm these associations, leading one to question if a reported association is accurate and reliable. We attempted to validate 44 published variants associated with TAC trough concentrations.

Materials & methods

Genotypes of the variants in our cohort of 1923 kidney allograft recipients were associated with TAC trough concentrations.

Results

Only variants in CYP3A4 and CYP3A5 were significantly associated with variation in TAC trough concentrations in our validation.

Conclusion

There is no evidence that common variants outside the CYP3A4 and CYP3A5 loci are associated with variation in TAC trough concentrations.

SUBMITTER: Oetting WS 

PROVIDER: S-EPMC6021962 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature